1.6M XNAS Volume
XNAS 25 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Christopher Anzalone | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Mar 2025 | 340,000 | 4,113,802 (4%) | 0% | 0 | Common Stock | |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 15.07 per share. | 13 Mar 2025 | 51,425 | 4,062,377 (3%) | 0% | 15.1 | 774,975 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.75 per share. | 03 Mar 2025 | 133,333 | 4,073,802 (4%) | 0% | 7.8 | 1,033,331 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 18.03 per share. | 03 Mar 2025 | 166,667 | 3,907,135 (3%) | 0% | 18.0 | 3,005,006 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 17.02 per share. | 03 Mar 2025 | 133,333 | 3,773,802 (3%) | 0% | 17.0 | 2,269,328 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2025 | 166,667 | 185,059 | - | - | Stock Option (right to buy Common Stock) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2025 | 133,333 | 51,726 | - | - | Stock Option (right to buy Common Stock) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.75 per share. | 03 Mar 2025 | 166,667 | 3,940,469 (3%) | 0% | 7.7 | 1,291,669 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 20.10 per share. | 07 Feb 2025 | 9,550 | 3,773,802 (3%) | 0% | 20.1 | 191,955 | Common Stock |
| Douglas S. Ingram | Director | Grant, award, or other acquisition of securities at price $ 20.09 per share. | 06 Feb 2025 | 38,396 | 38,396 (0%) | 0% | 20.1 | 771,376 | Common Stock |
| Adeoye Y. Olukotun | Director | Sale of securities on an exchange or to another person at price $ 21.00 per share. | 23 Jan 2025 | 959 | 35,781 (0%) | 0% | 21 | 20,139 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 04 Jan 2025 | 21,758 | 283,093 (0%) | 0% | 19.7 | 428,197 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 20.11 per share. | 04 Jan 2025 | 10,971 | 272,122 (0%) | 0% | 20.1 | 220,627 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2025 | 100,000 | 304,851 (0%) | 0% | 0 | Common Stock | |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.10 per share. | 04 Jan 2025 | 9,402 | 473,433 (0%) | 0% | 20.1 | 188,980 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.69 per share. | 04 Jan 2025 | 10,000 | 455,433 (0%) | 0% | 19.7 | 196,900 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.70 per share. | 04 Jan 2025 | 8,000 | 465,433 (0%) | 0% | 19.7 | 157,600 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2025 | 100,000 | 500,600 (0%) | 0% | 0 | Common Stock | |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 04 Jan 2025 | 17,765 | 482,835 (0%) | 0% | 19.7 | 349,615 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 19.69 per share. | 04 Jan 2025 | 8,000 | 527,201 (0%) | 0% | 19.7 | 157,520 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2025 | 100,000 | 564,385 (0%) | 0% | 0 | Common Stock | |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 19.69 per share. | 04 Jan 2025 | 19,658 | 544,727 (0%) | 0% | 19.7 | 387,066 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 20.10 per share. | 04 Jan 2025 | 9,526 | 535,201 (0%) | 0% | 20.1 | 191,473 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 19.05 per share. | 02 Jan 2025 | 11,520 | 3,764,252 (3%) | 0% | 19.1 | 219,456 | Common Stock |
| Adeoye Olukotun Y. | Director | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 27 Dec 2024 | 2,850 | 36,740 (0%) | 0% | 20 | 57,000 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 19.59 per share. | 23 Dec 2024 | 12,563 | 3,775,772 (3%) | 0% | 19.6 | 246,109 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 21.74 per share. | 18 Dec 2024 | 8,260 | 3,694,134 (3%) | 0% | 21.7 | 179,572 | Common Stock |
| Vakiener Victoria | Director | Grant, award, or other acquisition of securities at price $ 22.99 per share. | 18 Dec 2024 | 16,733 | 37,944 (0%) | 0% | 23.0 | 384,692 | Common Stock |
| Mauro Ferrari | Director | Grant, award, or other acquisition of securities at price $ 22.99 per share. | 18 Dec 2024 | 16,733 | 77,514 (0%) | 0% | 23.0 | 384,692 | Common Stock |
| Olukotun Y. Adeoye | Director | Grant, award, or other acquisition of securities at price $ 22.99 per share. | 18 Dec 2024 | 16,733 | 39,590 (0%) | 0% | 23.0 | 384,692 | Common Stock |
| Hongbo Lu | Director | Grant, award, or other acquisition of securities at price $ 22.99 per share. | 18 Dec 2024 | 16,733 | 47,163 (0%) | 0% | 23.0 | 384,692 | Common Stock |
| William D. Waddill | Director | Grant, award, or other acquisition of securities at price $ 22.99 per share. | 18 Dec 2024 | 16,733 | 57,111 (0%) | 0% | 23.0 | 384,692 | Common Stock |
| Anzalone Christopher | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 22.12 per share. | 18 Dec 2024 | 5,799 | 3,688,335 (3%) | 0% | 22.1 | 128,274 | Common Stock |
| Anzalone Christopher | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 20.52 per share. | 18 Dec 2024 | 12,653 | 3,702,394 (3%) | 0% | 20.5 | 259,640 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2024 | 100,000 | 3,788,335 (3%) | 0% | 0 | Common Stock | |
| Michael S. Perry | Director | Grant, award, or other acquisition of securities at price $ 22.99 per share. | 18 Dec 2024 | 16,733 | 131,490 (0%) | 0% | 23.0 | 384,692 | Common Stock |
| B. Given Douglas | Director | Sale of securities on an exchange or to another person at price $ 22.04 per share. | 16 Dec 2024 | 547 | 124,167 (0%) | 0% | 22.0 | 12,056 | Common Stock |
| B. Douglas Given | Director | Sale of securities on an exchange or to another person at price $ 21.90 per share. | 16 Dec 2024 | 5,000 | 124,714 (0%) | 0% | 21.9 | 109,500 | Common Stock |
| D. William Waddill | Director | Sale of securities on an exchange or to another person at price $ 21.90 per share. | 16 Dec 2024 | 3,748 | 44,125 (0%) | 0% | 21.9 | 82,081 | Common Stock |
| Victoria Vakiener | Director | Sale of securities on an exchange or to another person at price $ 21.91 per share. | 16 Dec 2024 | 8,994 | 21,211 (0%) | 0% | 21.9 | 197,059 | Common Stock |
| Waddill D. William | Director | Sale of securities on an exchange or to another person at price $ 22.04 per share. | 16 Dec 2024 | 3,747 | 40,378 (0%) | 0% | 22.0 | 82,584 | Common Stock |
| Hongbo Lu | Director | 30 Sep 2024 | 400 | 34,080 (0%) | 0% | 28 | 11,200 | Common Stock | |
| Hongbo Lu | Director | 30 Sep 2024 | 5,650 | 30,430 (0%) | 0% | 0 | Common Stock | ||
| Hongbo Lu | Director | 30 Sep 2024 | 500 | 36,080 (0%) | 0% | 22 | 11,000 | Common Stock | |
| Hongbo Lu | Director | 30 Sep 2024 | 500 | 35,580 (0%) | 0% | 25 | 12,500 | Common Stock | |
| Hongbo Lu | Director | 30 Sep 2024 | 150 | 35,080 (0%) | 0% | 27.3 | 4,101 | Common Stock | |
| Hongbo Lu | Director | 30 Sep 2024 | 850 | 34,930 (0%) | 0% | 27.5 | 23,375 | Common Stock | |
| Tracie Oliver | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 25.28 per share. | 02 Jul 2024 | 9,394 | 127,107 (0%) | 0% | 25.3 | 237,480 | Common Stock |
| Victoria Vakiener | Director | Sale of securities on an exchange or to another person at price $ 23.31 per share. | 02 May 2024 | 1,799 | 30,205 (0%) | 0% | 23.3 | 41,935 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 28.03 per share. | 01 Apr 2024 | 6,000 | 204,851 (0%) | 0% | 28.0 | 168,180 | Common Stock |
| Hongbo Lu | Director | Purchase of securities on an exchange or from another person at price $ 27.49 per share. | 18 Mar 2024 | 1,000 | 31,680 (0%) | 0% | 27.5 | 27,490 | Common Stock |
| Hongbo Lu | Director | Purchase of securities on an exchange or from another person at price $ 27.50 per share. | 18 Mar 2024 | 1,000 | 33,680 (0%) | 0% | 27.5 | 27,500 | Common Stock |
| Hongbo Lu | Director | Purchase of securities on an exchange or from another person at price $ 28.00 per share. | 18 Mar 2024 | 1,000 | 32,680 (0%) | 0% | 28 | 28,000 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 35.19 per share. | 06 Mar 2024 | 40,000 | 400,600 (0%) | 0% | 35.2 | 1,407,600 | Common Stock |
| Anzalone Christopher | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2024 | 57,499 | 351,726 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.16 per share. | 31 Jan 2024 | 37,769 | 3,734,778 (3%) | 0% | 32.2 | 1,214,651 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.54 per share. | 31 Jan 2024 | 57,499 | 3,772,547 (3%) | 0% | 14.5 | 836,035 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.71 per share. | 31 Jan 2024 | 19,730 | 3,715,048 (3%) | 0% | 32.7 | 645,368 | Common Stock |
| Hamilton James | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 36.47 per share. | 12 Jan 2024 | 4,238 | 214,553 (0%) | 0% | 36.5 | 154,560 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 37.37 per share. | 12 Jan 2024 | 3,702 | 210,851 (0%) | 0% | 37.4 | 138,344 | Common Stock |
| Mauro Ferrari | Director | Sale of securities on an exchange or to another person at price $ 38.63 per share. | 11 Jan 2024 | 1,000 | 60,778 (0%) | 0% | 38.6 | 38,630 | Common Stock |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 37.76 per share. | 11 Jan 2024 | 1,811 | 130,811 (0%) | 0% | 37.8 | 68,383 | Common Stock |
| D. Waddill William | Director | Sale of securities on an exchange or to another person at price $ 38.59 per share. | 11 Jan 2024 | 1,300 | 47,870 (0%) | 0% | 38.6 | 50,167 | Common Stock |
| B. Given Douglas | Director | Sale of securities on an exchange or to another person at price $ 38.55 per share. | 11 Jan 2024 | 1,100 | 129,711 (0%) | 0% | 38.6 | 42,405 | Common Stock |
| Mauro Ferrari | Director | Sale of securities on an exchange or to another person at price $ 37.80 per share. | 11 Jan 2024 | 2,147 | 61,778 (0%) | 0% | 37.8 | 81,157 | Common Stock |
| Waddill William D. | Director | Sale of securities on an exchange or to another person at price $ 37.81 per share. | 11 Jan 2024 | 2,634 | 49,170 (0%) | 0% | 37.8 | 99,592 | Common Stock |
| Vakiener Victoria | Director | Sale of securities on an exchange or to another person at price $ 38.84 per share. | 11 Jan 2024 | 1,100 | 32,001 (0%) | 0% | 38.8 | 42,724 | Common Stock |
| Vakiener Victoria | Director | Sale of securities on an exchange or to another person at price $ 37.87 per share. | 11 Jan 2024 | 3,620 | 33,101 (0%) | 0% | 37.9 | 137,089 | Common Stock |
| Martin Javier San | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 75,000 | 206,800 (0%) | 0% | 0 | Common Stock | |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 34.04 per share. | 04 Jan 2024 | 1,400 | 455,304 (0%) | 0% | 34.0 | 47,656 | Common Stock |
| San Javier Martin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.64 per share. | 04 Jan 2024 | 4,403 | 198,497 (0%) | 0% | 35.6 | 156,923 | Common Stock |
| Tracie Oliver | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 33.89 per share. | 04 Jan 2024 | 74 | 136,501 (0%) | 0% | 33.9 | 2,508 | Common Stock |
| Tracie Oliver | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 75,000 | 136,575 (0%) | 0% | 0 | Common Stock | |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 34.97 per share. | 04 Jan 2024 | 5,800 | 449,504 (0%) | 0% | 35.0 | 202,826 | Common Stock |
| Javier San Martin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 34.11 per share. | 04 Jan 2024 | 800 | 206,000 (0%) | 0% | 34.1 | 27,288 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 75,000 | 456,704 (0%) | 0% | 0 | Common Stock | |
| Javier San Martin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.03 per share. | 04 Jan 2024 | 3,100 | 202,900 (0%) | 0% | 35.0 | 108,593 | Common Stock |
| Myszkowski Kenneth | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 35.65 per share. | 04 Jan 2024 | 8,904 | 440,600 (0%) | 0% | 35.7 | 317,428 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 31.83 per share. | 03 Jan 2024 | 3,849 | 408,726 (0%) | 0% | 31.8 | 122,514 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 34.94 per share. | 03 Jan 2024 | 8,000 | 241,134 (0%) | 0% | 34.9 | 279,520 | Common Stock |
| Hamilton James | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 32.52 per share. | 03 Jan 2024 | 2,300 | 176,434 (0%) | 0% | 32.5 | 74,796 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 03 Jan 2024 | 10,000 | 218,791 (0%) | 0% | 35 | 350,000 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 35.65 per share. | 03 Jan 2024 | 12,741 | 464,385 (0%) | 0% | 35.7 | 454,217 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 35.65 per share. | 03 Jan 2024 | 12,343 | 228,791 (0%) | 0% | 35.7 | 440,028 | Common Stock |
| Hamilton James | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 03 Jan 2024 | 1,800 | 249,134 (0%) | 0% | 34 | 61,200 | Common Stock |
| Hamilton James | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 33.30 per share. | 03 Jan 2024 | 500 | 175,934 (0%) | 0% | 33.3 | 16,650 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 33.99 per share. | 03 Jan 2024 | 1,900 | 485,326 (0%) | 0% | 34.0 | 64,581 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 85,000 | 487,226 (0%) | 0% | 0 | Common Stock | |
| O'Brien Patrick | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 33.41 per share. | 03 Jan 2024 | 400 | 405,526 (0%) | 0% | 33.4 | 13,364 | Common Stock |
| Hamilton James | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 31.81 per share. | 03 Jan 2024 | 3,500 | 178,734 (0%) | 0% | 31.8 | 111,335 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2024 | 75,000 | 250,934 (0%) | 0% | 0 | Common Stock | |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 32.63 per share. | 03 Jan 2024 | 1,600 | 402,226 (0%) | 0% | 32.6 | 52,208 | Common Stock |
| O'Brien Patrick | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 34.99 per share. | 03 Jan 2024 | 8,200 | 477,126 (0%) | 0% | 35.0 | 286,918 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 32.52 per share. | 03 Jan 2024 | 2,800 | 405,926 (0%) | 0% | 32.5 | 91,056 | Common Stock |
| O'Brien Patrick | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 32.65 per share. | 03 Jan 2024 | 1,700 | 403,826 (0%) | 0% | 32.7 | 55,505 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 31.25 per share. | 02 Jan 2024 | 5,318 | 3,715,048 (3%) | 0% | 31.3 | 166,188 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 30.74 per share. | 02 Jan 2024 | 4,634 | 3,720,366 (3%) | 0% | 30.7 | 142,449 | Common Stock |
| Anzalone Christopher | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.54 per share. | 20 Dec 2023 | 12,000 | 3,725,000 (3%) | 0% | 28.5 | 342,480 | Common Stock |
| Michael Perry S. | Director | Grant, award, or other acquisition of securities at price $ 25.41 per share. | 15 Dec 2023 | 14,987 | 114,754 (0%) | 0% | 25.4 | 380,820 | Common Stock |
| Ferrari Mauro | Director | Grant, award, or other acquisition of securities at price $ 25.41 per share. | 15 Dec 2023 | 14,987 | 65,825 (0%) | 0% | 25.4 | 380,820 | Common Stock |
| B. Given Douglas | Director | Grant, award, or other acquisition of securities at price $ 25.41 per share. | 15 Dec 2023 | 14,987 | 132,622 (0%) | 0% | 25.4 | 380,820 | Common Stock |
| Vakiener Victoria | Director | Grant, award, or other acquisition of securities at price $ 25.41 per share. | 15 Dec 2023 | 14,987 | 36,721 (0%) | 0% | 25.4 | 380,820 | Common Stock |
| William D. Waddill | Director | Grant, award, or other acquisition of securities at price $ 25.41 per share. | 15 Dec 2023 | 14,987 | 51,804 (0%) | 0% | 25.4 | 380,820 | Common Stock |
| Y. Adeoye Olukotun | Director | Grant, award, or other acquisition of securities at price $ 25.41 per share. | 15 Dec 2023 | 14,987 | 22,854 (0%) | 0% | 25.4 | 380,820 | Common Stock |
| Tracie Oliver | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 35.31 per share. | 03 Jul 2023 | 8,925 | 61,575 (0%) | 0% | 35.3 | 315,142 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 35.53 per share. | 30 Jun 2023 | 3,000 | 188,484 (0%) | 0% | 35.5 | 106,590 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 36.20 per share. | 27 Jun 2023 | 15,000 | 381,704 (0%) | 0% | 36.2 | 543,000 | Common Stock |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 40.90 per share. | 05 May 2023 | 6,500 | 117,635 (0%) | 0% | 40.9 | 265,850 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.01 per share. | 03 May 2023 | 54,928 | 3,816,266 (3%) | 0% | 2.0 | 110,405 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 39.14 per share. | 03 May 2023 | 54,928 | 3,761,338 (3%) | 0% | 39.1 | 2,149,882 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2023 | 50,000 | 466,980 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2023 | 54,928 | 516,980 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.02 per share. | 03 May 2023 | 25,992 | 3,761,338 (3%) | 0% | 40.0 | 1,040,200 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 38.97 per share. | 03 May 2023 | 24,008 | 3,787,330 (3%) | 0% | 39.0 | 935,592 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.01 per share. | 03 May 2023 | 50,000 | 3,811,338 (3%) | 0% | 2.0 | 100,500 | Common Stock |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 32.62 per share. | 27 Feb 2023 | 875 | 13,000 (0%) | 0% | 32.6 | 28,543 | Common Stock |
| Douglas B. Given | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 4,593 | 4,593 | - | - | Common Stock | |
| Douglas B. Given | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 7,867 | 124,135 (0%) | 0% | 0 | Common Stock | |
| Michael S. Perry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 7,867 | 99,767 (0%) | 0% | 0 | Common Stock | |
| Michael S. Perry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 4,593 | 4,593 | - | - | Common Stock | |
| Mauro Ferrari | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 7,867 | 50,838 (0%) | 0% | 0 | Common Stock | |
| Mauro Ferrari | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 4,593 | 4,593 | - | - | Common Stock | |
| Marianne De Backer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 4,593 | 4,593 | - | - | Common Stock | |
| Marianne De Backer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 7,867 | 31,267 (0%) | 0% | 0 | Common Stock | |
| Victoria Vakiener | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 7,867 | 23,284 (0%) | 0% | 0 | Common Stock | |
| Victoria Vakiener | Director | Sale or transfer of securities back to the company at price $ 0.00 per share. | 10 Jan 2023 | 1,764 | 15,417 (0%) | 0% | 0 | Common Stock | |
| Victoria Vakiener | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 4,593 | 4,593 | - | - | Common Stock | |
| William D. Waddill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2023 | 7,867 | 36,817 (0%) | 0% | 0 | Common Stock | |
| William D. Waddill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2023 | 4,593 | 4,593 | - | - | Common Stock | |
| William D. Waddill | Director | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 09 Jan 2023 | 3,200 | 28,950 (0%) | 0% | 30 | 96,000 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 37.40 per share. | 05 Jan 2023 | 6,573 | 191,484 (0%) | 0% | 37.4 | 245,830 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 37.40 per share. | 05 Jan 2023 | 7,230 | 198,057 (0%) | 0% | 37.4 | 270,402 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 37.39 per share. | 05 Jan 2023 | 7,500 | 413,375 (0%) | 0% | 37.4 | 280,425 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 37.39 per share. | 05 Jan 2023 | 7,500 | 420,875 (0%) | 0% | 37.4 | 280,425 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2023 | 60,000 | 396,704 (0%) | 0% | 0 | Common Stock | |
| Martin Javier San | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2023 | 60,000 | 151,500 (0%) | 0% | 0 | Common Stock | |
| Tracie Oliver | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2023 | 500 | 70,500 (0%) | 0% | 0 | Common Stock | |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 40.52 per share. | 03 Jan 2023 | 247 | 145,287 (0%) | 0% | 40.5 | 10,008 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 38.52 per share. | 03 Jan 2023 | 3,682 | 145,834 (0%) | 0% | 38.5 | 141,831 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 39.56 per share. | 03 Jan 2023 | 300 | 145,534 (0%) | 0% | 39.6 | 11,868 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 37.49 per share. | 03 Jan 2023 | 1,642 | 149,516 (0%) | 0% | 37.5 | 61,559 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 40.54 per share. | 03 Jan 2023 | 136 | 151,158 (0%) | 0% | 40.5 | 5,513 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 39.74 per share. | 03 Jan 2023 | 300 | 151,294 (0%) | 0% | 39.7 | 11,922 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 37.46 per share. | 03 Jan 2023 | 1,194 | 154,431 (0%) | 0% | 37.5 | 44,727 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Sale of securities on an exchange or to another person at price $ 38.53 per share. | 03 Jan 2023 | 2,837 | 151,594 (0%) | 0% | 38.5 | 109,310 | Common Stock |
| James Hamilton | Chief Discovery/Trans Medicine | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 60,000 | 205,287 (0%) | 0% | 0 | Common Stock | |
| Patrick O'Brien | COO and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 65,000 | 428,375 (0%) | 0% | 0 | Common Stock | |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 40.53 per share. | 03 Jan 2023 | 270 | 363,375 (0%) | 0% | 40.5 | 10,943 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 39.55 per share. | 03 Jan 2023 | 300 | 363,645 (0%) | 0% | 39.6 | 11,865 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 38.58 per share. | 03 Jan 2023 | 5,286 | 363,945 (0%) | 0% | 38.6 | 203,934 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 37.58 per share. | 03 Jan 2023 | 2,894 | 369,231 (0%) | 0% | 37.6 | 108,757 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 40.80 per share. | 03 Jan 2023 | 70 | 372,125 (0%) | 0% | 40.8 | 2,856 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 39.74 per share. | 03 Jan 2023 | 500 | 372,195 (0%) | 0% | 39.7 | 19,870 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 38.54 per share. | 03 Jan 2023 | 5,527 | 372,695 (0%) | 0% | 38.5 | 213,011 | Common Stock |
| Patrick O'Brien | COO and General Counsel | Sale of securities on an exchange or to another person at price $ 37.53 per share. | 03 Jan 2023 | 2,653 | 378,222 (0%) | 0% | 37.5 | 99,567 | Common Stock |
| Patrick O'Brien | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 21 Dec 2022 | 32,000 | 380,875 (0%) | 0% | 6.2 | 196,800 | Common Stock |
| Patrick O'Brien | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Dec 2022 | 32,000 | 0 | - | - | Stock Option (right to buy Common Stock) | |
| Christopher Anzalone | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2022 | 234,025 | 3,720,714 (3%) | 0% | 0 | Common Stock | |
| Christopher Anzalone | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2022 | 18,375 | 3,486,689 (3%) | 0% | 0 | Common Stock | |
| Martin Javier San | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.98 per share. | 21 Nov 2022 | 19,300 | 91,700 (0%) | 0% | 30.0 | 578,614 | COMMON STOCK |
| Martin Javier San | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.62 per share. | 21 Nov 2022 | 200 | 91,500 (0%) | 0% | 30.6 | 6,124 | COMMON STOCK |
| Kenneth Myszkowski | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Sep 2022 | 96,676 | 367,329 (0%) | 0% | 0 | Common Stock | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.77 per share. | 27 Sep 2022 | 39,082 | 3,469,856 (3%) | 0% | 30.8 | 1,202,553 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.21 per share. | 27 Sep 2022 | 1,542 | 3,468,314 (3%) | 0% | 31.2 | 48,126 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale or transfer of securities back to the company at price $ 0.00 per share. | 08 Jul 2022 | 551,197 | 3,508,938 (3%) | 0% | 0 | Common Stock | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2022 | 2,501 | 612,532 | - | - | Stock Option (right to buy Common Stock) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.54 per share. | 07 Jul 2022 | 2,501 | 4,060,135 (3%) | 0% | 14.5 | 36,365 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 53.11 per share. | 11 Feb 2022 | 40,853 | 4,163,169 (4%) | 0% | 53.1 | 2,169,703 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Feb 2022 | 146,388 | 615,033 | - | - | Stock Option (right to buy Common Stock) | |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.51 per share. | 11 Feb 2022 | 1,900 | 4,057,634 (3%) | 0% | 50.5 | 95,969 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.90 per share. | 11 Feb 2022 | 61,482 | 4,059,534 (3%) | 0% | 50.9 | 3,129,434 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 52.28 per share. | 11 Feb 2022 | 42,153 | 4,121,016 (4%) | 0% | 52.3 | 2,203,759 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 11 Feb 2022 | 146,388 | 4,204,022 (4%) | 0% | 5.2 | 759,754 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 62.00 per share. | 05 Jan 2022 | 16,528 | 471,569 (0%) | 0% | 62 | 1,024,736 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 60.50 per share. | 05 Jan 2022 | 15,908 | 488,097 (0%) | 0% | 60.5 | 962,434 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 63.17 per share. | 05 Jan 2022 | 3,778 | 467,791 (0%) | 0% | 63.2 | 238,656 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 63.95 per share. | 05 Jan 2022 | 3,786 | 464,005 (0%) | 0% | 64.0 | 242,115 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 64.89 per share. | 04 Jan 2022 | 9,955 | 171,295 (0%) | 0% | 64.9 | 645,980 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 64.35 per share. | 04 Jan 2022 | 60 | 155,625 (0%) | 0% | 64.4 | 3,861 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 63.68 per share. | 04 Jan 2022 | 700 | 155,685 (0%) | 0% | 63.7 | 44,576 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 62.64 per share. | 04 Jan 2022 | 1,100 | 156,385 (0%) | 0% | 62.6 | 68,904 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 61.84 per share. | 04 Jan 2022 | 2,100 | 157,485 (0%) | 0% | 61.8 | 129,864 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 60.51 per share. | 04 Jan 2022 | 2,290 | 159,585 (0%) | 0% | 60.5 | 138,568 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 69.38 per share. | 04 Jan 2022 | 500 | 161,875 (0%) | 0% | 69.4 | 34,690 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 68.12 per share. | 04 Jan 2022 | 649 | 162,375 (0%) | 0% | 68.1 | 44,210 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 67.39 per share. | 04 Jan 2022 | 802 | 163,024 (0%) | 0% | 67.4 | 54,047 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 65.59 per share. | 04 Jan 2022 | 7,469 | 163,826 (0%) | 0% | 65.6 | 489,892 | Common Stock |
| Michael S. Perry | Director | Sale of securities on an exchange or to another person at price $ 64.30 per share. | 03 Jan 2022 | 2,628 | 87,372 (0%) | 0% | 64.3 | 168,980 | Common Stock |
| Michael S. Perry | Director | Sale of securities on an exchange or to another person at price $ 65.12 per share. | 03 Jan 2022 | 1,600 | 85,772 (0%) | 0% | 65.1 | 104,192 | Common Stock |
| Michael S. Perry | Director | Sale of securities on an exchange or to another person at price $ 66.25 per share. | 03 Jan 2022 | 272 | 85,500 (0%) | 0% | 66.3 | 18,020 | Common Stock |
| William D. Waddill | Director | Sale of securities on an exchange or to another person at price $ 64.23 per share. | 03 Jan 2022 | 2,100 | 28,150 (0%) | 0% | 64.2 | 134,883 | Common Stock |
| William D. Waddill | Director | Sale of securities on an exchange or to another person at price $ 66.25 per share. | 03 Jan 2022 | 272 | 25,750 (0%) | 0% | 66.3 | 18,020 | Common Stock |
| William D. Waddill | Director | Sale of securities on an exchange or to another person at price $ 65.01 per share. | 03 Jan 2022 | 2,128 | 26,022 (0%) | 0% | 65.0 | 138,341 | Common Stock |
| Marianne De Backer | Director | Sale of securities on an exchange or to another person at price $ 65.01 per share. | 03 Jan 2022 | 1,984 | 17,272 (0%) | 0% | 65.0 | 128,980 | Common Stock |
| Marianne De Backer | Director | Sale of securities on an exchange or to another person at price $ 64.25 per share. | 03 Jan 2022 | 2,244 | 19,256 (0%) | 0% | 64.3 | 144,177 | Common Stock |
| Marianne De Backer | Director | Sale of securities on an exchange or to another person at price $ 66.25 per share. | 03 Jan 2022 | 272 | 17,000 (0%) | 0% | 66.3 | 18,020 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2022 | 800,000 | 4,045,828 (3%) | 0% | 0 | Common Stock | |
| James Hamilton | Senior Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2022 | 55,000 | 181,250 (0%) | 0% | 0 | Common Stock | |
| Kenneth Myszkowski | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2022 | 60,000 | 504,005 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Purchase of securities on an exchange or from another person at price $ 66.37 per share. | 28 Dec 2021 | 655 | 109,868 (0%) | 0% | 66.4 | 43,472 | Common Stock |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Dec 2021 | 655 | 109,213 (0%) | 0% | 0 | Common Stock | |
| Mauro Ferrari | Director | Sale of securities on an exchange or to another person at price $ 66.82 per share. | 28 Dec 2021 | 3,400 | 36,571 (0%) | 0% | 66.8 | 227,188 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Dec 2021 | 11,806 | 773,227 | - | - | Stock Option (right to buy Common Stock) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 23 Dec 2021 | 11,806 | 3,245,828 (3%) | 0% | 5.2 | 61,273 | Common Stock |
| Martin Javier San | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 69.01 per share. | 19 Nov 2021 | 13,704 | 116,796 (0%) | 0% | 69.0 | 945,713 | Common Stock |
| Martin Javier San | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 70.99 per share. | 19 Nov 2021 | 100 | 111,000 (0%) | 0% | 71.0 | 7,099 | Common Stock |
| Martin Javier San | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 70.01 per share. | 19 Nov 2021 | 5,696 | 111,100 (0%) | 0% | 70.0 | 398,777 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 65.57 per share. | 20 Oct 2021 | 44,170 | 3,284,852 (3%) | 0% | 65.6 | 2,896,227 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 66.09 per share. | 20 Oct 2021 | 5,830 | 3,279,022 (3%) | 0% | 66.1 | 385,305 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 66.23 per share. | 20 Oct 2021 | 15,000 | 3,329,022 (3%) | 0% | 66.2 | 993,450 | Common Stock |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 65.24 per share. | 09 Sep 2021 | 5,000 | 109,868 (0%) | 0% | 65.2 | 326,200 | Common Stock |
| Marianne De Backer | Director | Sale of securities on an exchange or to another person at price $ 89.85 per share. | 24 Jun 2021 | 5,000 | 21,500 (0%) | 0% | 89.9 | 449,250 | Common Stock |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 89.21 per share. | 22 Jun 2021 | 4,500 | 114,868 (0%) | 0% | 89.2 | 401,445 | Common Stock |
| James Hassard | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 89.22 per share. | 22 Jun 2021 | 3,625 | 105,750 (0%) | 0% | 89.2 | 323,423 | Common Stock |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 88.73 per share. | 22 Feb 2021 | 1,125 | 13,875 (0%) | 0% | 88.7 | 99,821 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 88.88 per share. | 08 Feb 2021 | 45,348 | 298,811 (0%) | 0% | 88.9 | 4,030,530 | Common Stock |
| Patrick O'Brien | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2021 | 90,000 | 60,000 | - | - | Stock Option (right to buy) | |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 89.66 per share. | 08 Feb 2021 | 5,436 | 293,375 (0%) | 0% | 89.7 | 487,392 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 86.72 per share. | 08 Feb 2021 | 7,961 | 375,414 (0%) | 0% | 86.7 | 690,378 | Common Stock |
| Patrick O'Brien | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.22 per share. | 08 Feb 2021 | 90,000 | 383,375 (0%) | 0% | 5.2 | 469,800 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 88.08 per share. | 08 Feb 2021 | 31,255 | 344,159 (0%) | 0% | 88.1 | 2,752,940 | Common Stock |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 83.28 per share. | 15 Jan 2021 | 3,000 | 12,500 (0%) | 0% | 83.3 | 249,840 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 81.82 per share. | 14 Jan 2021 | 3,814 | 126,250 (0%) | 0% | 81.8 | 312,061 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 80.97 per share. | 14 Jan 2021 | 6,186 | 130,064 (0%) | 0% | 81.0 | 500,880 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 81.00 per share. | 11 Jan 2021 | 1,441 | 444,005 (0%) | 0% | 81 | 116,721 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 81.02 per share. | 11 Jan 2021 | 11,597 | 445,446 (0%) | 0% | 81.0 | 939,589 | Common Stock |
| James Hassard | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 75.00 per share. | 07 Jan 2021 | 15,625 | 109,375 (0%) | 0% | 75 | 1,171,875 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 71.77 per share. | 06 Jan 2021 | 4,359 | 482,209 (0%) | 0% | 71.8 | 312,845 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 72.63 per share. | 06 Jan 2021 | 25,166 | 457,043 (0%) | 0% | 72.6 | 1,827,807 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 70.75 per share. | 06 Jan 2021 | 1,100 | 486,568 (0%) | 0% | 70.8 | 77,825 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 70.78 per share. | 06 Jan 2021 | 1,142 | 317,233 (0%) | 0% | 70.8 | 80,831 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 72.67 per share. | 06 Jan 2021 | 13,243 | 293,375 (0%) | 0% | 72.7 | 962,369 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 72.27 per share. | 06 Jan 2021 | 10,615 | 306,618 (0%) | 0% | 72.3 | 767,146 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 72.19 per share. | 05 Jan 2021 | 3,300 | 167,900 (0%) | 0% | 72.2 | 238,227 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 72.67 per share. | 05 Jan 2021 | 14,708 | 136,250 (0%) | 0% | 72.7 | 1,068,830 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 72.05 per share. | 05 Jan 2021 | 3,967 | 150,958 (0%) | 0% | 72.0 | 285,822 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 70.89 per share. | 05 Jan 2021 | 700 | 154,925 (0%) | 0% | 70.9 | 49,623 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 73.93 per share. | 05 Jan 2021 | 1,925 | 155,625 (0%) | 0% | 73.9 | 142,315 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 72.91 per share. | 05 Jan 2021 | 10,350 | 157,550 (0%) | 0% | 72.9 | 754,619 | Common Stock |
| James Hamilton | Senior Vice President | Sale of securities on an exchange or to another person at price $ 71.09 per share. | 05 Jan 2021 | 3,800 | 171,200 (0%) | 0% | 71.1 | 270,142 | Common Stock |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 76.08 per share. | 01 Jan 2021 | 4,000 | 119,368 (0%) | 0% | 76.1 | 304,320 | Common Stock |
| Douglas B. Given | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 9,500 | 123,368 (0%) | 0% | 0 | Common Stock | |
| Michael S. Perry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 9,000 | 94,000 (0%) | 0% | 0 | Common Stock | |
| Michael S. Perry | Director | Sale of securities on an exchange or to another person at price $ 76.09 per share. | 01 Jan 2021 | 4,000 | 90,000 (0%) | 0% | 76.1 | 304,360 | Common Stock Sold |
| James Hamilton | Senior Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 50,000 | 175,000 (0%) | 0% | 0 | Common Stock | |
| Kenneth Myszkowski | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 60,000 | 487,668 (0%) | 0% | 0 | Common Stock | |
| Mauro Ferrari | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 9,000 | 39,971 (0%) | 0% | 0 | Common Stock | |
| William D. Waddill | Director | Sale of securities on an exchange or to another person at price $ 76.08 per share. | 01 Jan 2021 | 3,750 | 30,250 (0%) | 0% | 76.1 | 285,300 | Common Stock |
| William D. Waddill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 9,000 | 34,000 (0%) | 0% | 0 | Common Stock | |
| Patrick O'Brien | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 60,000 | 318,375 (0%) | 0% | 0 | Common Stock | |
| Marianne De Backer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2021 | 9,000 | 26,500 (0%) | 0% | 0 | Common Stock | |
| Christopher Anzalone | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Dec 2020 | 1,126 | 2,544,621 (2%) | 0% | 0 | Common Stock | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share. | 18 Dec 2020 | 12,236 | 2,517,473 (2%) | 0% | 4.8 | 58,121 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2020 | 28,274 | 800,033 | - | - | Common Stock (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 18 Dec 2020 | 28,274 | 2,545,747 (2%) | 0% | 6.1 | 173,885 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2020 | 12,236 | 828,307 | - | - | Common Stock (right to buy) | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Dec 2020 | 35 | 114,173 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Dec 2020 | 35 | 114,138 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Dec 2020 | 200 | 113,938 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Dec 2020 | 35 | 113,903 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Dec 2020 | 35 | 113,868 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Dec 2020 | 65 | 114,673 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Dec 2020 | 65 | 114,608 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Dec 2020 | 200 | 114,408 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Dec 2020 | 200 | 114,208 (0%) | 0% | 0 | Common Stock | |
| William D. Waddill | Director | Sale of securities on an exchange or to another person at price $ 73.10 per share. | 10 Dec 2020 | 1,800 | 25,000 (0%) | 0% | 73.1 | 131,580 | Common Stock |
| William D. Waddill | Director | Sale of securities on an exchange or to another person at price $ 68.50 per share. | 10 Dec 2020 | 1,200 | 26,800 (0%) | 0% | 68.5 | 82,200 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 67.97 per share. | 08 Dec 2020 | 16,324 | 2,505,237 (2%) | 0% | 68.0 | 1,109,542 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 70.87 per share. | 08 Dec 2020 | 5,880 | 2,509,240 (2%) | 0% | 70.9 | 416,716 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 69.80 per share. | 08 Dec 2020 | 12,067 | 2,515,120 (2%) | 0% | 69.8 | 842,277 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 67.27 per share. | 08 Dec 2020 | 16,726 | 2,527,187 (2%) | 0% | 67.3 | 1,125,158 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.01 per share. | 08 Dec 2020 | 38,676 | 2,543,913 (2%) | 0% | 2.0 | 77,739 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.01 per share. | 08 Dec 2020 | 16,324 | 2,521,561 (2%) | 0% | 2.0 | 32,811 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Dec 2020 | 38,676 | 840,543 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Dec 2020 | 16,324 | 879,219 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 71.61 per share. | 08 Dec 2020 | 4,003 | 2,505,237 (2%) | 0% | 71.6 | 286,655 | Common Stock |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 79.30 per share. | 07 Dec 2020 | 9,075 | 114,738 (0%) | 0% | 79.3 | 719,648 | Common Stock |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Dec 2020 | 15,500 | 15,500 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Dec 2020 | 15,500 | 15,500 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Dec 2020 | 31,000 | 123,813 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 79.59 per share. | 07 Dec 2020 | 500 | 15,000 (0%) | 0% | 79.6 | 39,795 | Common Stock |
| Curt Bradshaw | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 69.39 per share. | 19 Nov 2020 | 15,625 | 15,625 (0%) | 0% | 69.4 | 1,084,219 | Common Stock |
| Curt Bradshaw | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 68.73 per share. | 19 Nov 2020 | 15,625 | 0 (0%) | 0% | 68.7 | 1,073,906 | Common Stock |
| Martin Javier San | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 69.39 per share. | 19 Nov 2020 | 19,500 | 130,500 (0%) | 0% | 69.4 | 1,353,105 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 69.04 per share. | 09 Nov 2020 | 25,840 | 445,333 (0%) | 0% | 69.0 | 1,783,994 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Nov 2020 | 43,505 | 0 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 69.86 per share. | 09 Nov 2020 | 17,665 | 427,668 (0%) | 0% | 69.9 | 1,234,077 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.54 per share. | 09 Nov 2020 | 43,505 | 471,173 (0%) | 0% | 14.5 | 632,563 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 58.57 per share. | 23 Oct 2020 | 12,272 | 2,505,237 (2%) | 0% | 58.6 | 718,771 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 58.16 per share. | 23 Oct 2020 | 87,728 | 2,517,509 (2%) | 0% | 58.2 | 5,102,260 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 54.04 per share. | 20 Oct 2020 | 29,166 | 427,668 (0%) | 0% | 54.0 | 1,576,131 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 20 Oct 2020 | 29,166 | 456,834 (0%) | 0% | 6.2 | 179,371 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Oct 2020 | 29,166 | 43,505 | - | - | Stock Option (right to buy) | |
| Mauro Ferrari | Director | Sale of securities on an exchange or to another person at price $ 48.00 per share. | 09 Oct 2020 | 10,000 | 30,971 (0%) | 0% | 48 | 480,000 | Common Stock |
| Marianne De Backer | Director | Purchase of securities on an exchange or from another person at price $ 50.00 per share. | 08 Oct 2020 | 500 | 17,500 (0%) | 0% | 50 | 25,000 | Common Stock |
| Marianne De Backer | Director | Purchase of securities on an exchange or from another person at price $ 50.93 per share. | 08 Oct 2020 | 500 | 17,000 (0%) | 0% | 50.9 | 25,465 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.35 per share. | 13 Aug 2020 | 50,000 | 2,605,237 (2%) | 0% | 41.4 | 2,067,500 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.90 per share. | 13 Aug 2020 | 50,000 | 2,655,237 (2%) | 0% | 9.9 | 495,000 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2020 | 50,000 | 895,543 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 39.57 per share. | 25 Jun 2020 | 23 | 2,605,237 (2%) | 0% | 39.6 | 910 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 38.81 per share. | 25 Jun 2020 | 99,977 | 2,605,260 (2%) | 0% | 38.8 | 3,880,107 | Common Stock |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2020 | 10,000 | 40,000 | - | - | Common Stock (right to buy) | |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share. | 14 May 2020 | 7,000 | 15,000 (0%) | 0% | 4.8 | 33,250 | Common Stock |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 14 May 2020 | 15,000 | 60,000 (0%) | 0% | 5.2 | 77,850 | Common Stock |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2020 | 25,000 | 0 | - | - | Common Stock (right to buy) | |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2020 | 15,000 | 25,000 | - | - | Common Stock (right to buy) | |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.19 per share. | 14 May 2020 | 15,000 | 35,000 (0%) | 0% | 2.2 | 32,850 | Common Stock |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.01 per share. | 14 May 2020 | 5,000 | 20,000 (0%) | 0% | 2.0 | 10,050 | Common Stock |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2020 | 7,000 | 70,000 | - | - | Common Stock (right to buy) | |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.20 per share. | 14 May 2020 | 25,000 | 85,000 (0%) | 0% | 4.2 | 105,000 | Common Stock |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.62 per share. | 14 May 2020 | 10,000 | 45,000 (0%) | 0% | 2.6 | 26,200 | Common Stock |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2020 | 15,000 | 50,000 | - | - | Common Stock (right to buy) | |
| Michael S. Perry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2020 | 5,000 | 65,000 | - | - | Common Stock (right to buy) | |
| Michael S. Perry | Director | Sale of securities on an exchange or to another person at price $ 36.42 per share. | 12 May 2020 | 6,100 | 8,000 (0%) | 0% | 36.4 | 222,162 | Common Stock |
| Michael S. Perry | Director | Sale of securities on an exchange or to another person at price $ 35.71 per share. | 12 May 2020 | 29,900 | 14,100 (0%) | 0% | 35.7 | 1,067,729 | Common Stock |
| William D. Waddill | Director | Sale of securities on an exchange or to another person at price $ 36.54 per share. | 11 May 2020 | 26,000 | 28,000 (0%) | 0% | 36.5 | 950,040 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 27 Apr 2020 | 100 | 851,634 (0%) | 0% | 40 | 4,000 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 27 Apr 2020 | 200 | 851,934 (0%) | 0% | 5.2 | 1,038 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 27 Apr 2020 | 200 | 851,734 (0%) | 0% | 40 | 8,000 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.75 per share. | 27 Apr 2020 | 500 | 852,134 (0%) | 0% | 7.8 | 3,875 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.54 per share. | 27 Apr 2020 | 1,454 | 853,588 (0%) | 0% | 14.5 | 21,141 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share. | 27 Apr 2020 | 1,200 | 854,788 (0%) | 0% | 4.8 | 5,700 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 27 Apr 2020 | 830 | 855,618 (0%) | 0% | 5.2 | 4,308 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.20 per share. | 27 Apr 2020 | 213 | 855,831 (0%) | 0% | 5.2 | 1,108 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 27 Apr 2020 | 500 | 855,331 (0%) | 0% | 40 | 20,000 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 27 Apr 2020 | 1,454 | 853,877 (0%) | 0% | 40 | 58,160 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 27 Apr 2020 | 1,200 | 852,677 (0%) | 0% | 40 | 48,000 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 27 Apr 2020 | 830 | 851,847 (0%) | 0% | 40 | 33,200 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 27 Apr 2020 | 213 | 851,634 (0%) | 0% | 40 | 8,520 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 27 Apr 2020 | 204 | 851,430 (0%) | 0% | 40 | 8,160 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 27 Apr 2020 | 700 | 850,730 (0%) | 0% | 40 | 28,000 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2020 | 200 | 333,544 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2020 | 500 | 333,044 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2020 | 1,454 | 331,590 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2020 | 1,200 | 330,390 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2020 | 830 | 329,560 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2020 | 213 | 329,347 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 20 Apr 2020 | 5,300 | 858,993 (0%) | 0% | 40 | 212,000 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 20 Apr 2020 | 3,454 | 855,539 (0%) | 0% | 40 | 138,160 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 20 Apr 2020 | 3,456 | 864,293 (0%) | 0% | 40 | 138,240 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share. | 20 Apr 2020 | 3,800 | 862,793 (0%) | 0% | 4.8 | 18,050 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 20 Apr 2020 | 3,700 | 866,493 (0%) | 0% | 5.2 | 19,203 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.20 per share. | 20 Apr 2020 | 3,456 | 869,949 (0%) | 0% | 5.2 | 17,971 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.54 per share. | 20 Apr 2020 | 5,300 | 875,249 (0%) | 0% | 14.5 | 77,062 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 20 Apr 2020 | 3,800 | 871,449 (0%) | 0% | 40 | 152,000 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Apr 2020 | 5,300 | 333,744 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Apr 2020 | 3,456 | 339,044 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 20 Apr 2020 | 3,700 | 867,749 (0%) | 0% | 40 | 148,000 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Apr 2020 | 3,700 | 342,500 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Apr 2020 | 3,800 | 346,200 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 20 Apr 2020 | 3,805 | 851,734 (0%) | 0% | 40 | 152,200 | Common Stock |
| Douglas B. Given | Director | Sale of securities on an exchange or to another person at price $ 36.89 per share. | 14 Apr 2020 | 25,000 | 155,925 (0%) | 0% | 36.9 | 922,250 | Common Stock |
| Douglas B. Given | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Apr 2020 | 1,112 | 154,813 (0%) | 0% | 0 | Common Stock | |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.90 per share. | 25 Feb 2020 | 12,000 | 396,223 (0%) | 0% | 9.9 | 118,800 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Feb 2020 | 10,834 | 72,671 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Feb 2020 | 12,116 | 83,505 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Feb 2020 | 6,495 | 95,621 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Feb 2020 | 2,000 | 102,116 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Feb 2020 | 12,000 | 104,116 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 25 Feb 2020 | 10,834 | 427,668 (0%) | 0% | 6.1 | 66,629 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.75 per share. | 25 Feb 2020 | 12,116 | 416,834 (0%) | 0% | 7.8 | 93,899 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.54 per share. | 25 Feb 2020 | 6,495 | 404,718 (0%) | 0% | 14.5 | 94,437 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 25 Feb 2020 | 2,000 | 398,223 (0%) | 0% | 5.2 | 10,380 | Common Stock |
| Mauro Ferrari | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2020 | 26,571 | 40,971 (0%) | 0% | 0 | Common Stock | |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 47.07 per share. | 21 Jan 2020 | 6,397 | 418,139 (0%) | 0% | 47.1 | 301,107 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 47.93 per share. | 21 Jan 2020 | 6,432 | 411,707 (0%) | 0% | 47.9 | 308,286 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 49.07 per share. | 21 Jan 2020 | 10,554 | 401,153 (0%) | 0% | 49.1 | 517,885 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 21 Jan 2020 | 33,351 | 424,536 (0%) | 0% | 5.2 | 173,092 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 51.11 per share. | 21 Jan 2020 | 10,680 | 387,673 (0%) | 0% | 51.1 | 545,855 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 52.13 per share. | 21 Jan 2020 | 3,450 | 384,223 (0%) | 0% | 52.1 | 179,849 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jan 2020 | 33,351 | 116,116 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 49.98 per share. | 21 Jan 2020 | 2,800 | 398,353 (0%) | 0% | 50.0 | 139,944 | Common Stock |
| Marianne De Backer | Director | Purchase of securities on an exchange or from another person at price $ 24.80 per share. | 13 Jan 2020 | 500 | 15,000 (0%) | 0% | 24.8 | 12,400 | Common Stock |
| Marianne De Backer | Director | Purchase of securities on an exchange or from another person at price $ 54.95 per share. | 13 Jan 2020 | 500 | 13,000 (0%) | 0% | 55.0 | 27,475 | Common Stock |
| Marianne De Backer | Director | Purchase of securities on an exchange or from another person at price $ 35.07 per share. | 13 Jan 2020 | 500 | 13,500 (0%) | 0% | 35.1 | 17,535 | Common Stock |
| Marianne De Backer | Director | Purchase of securities on an exchange or from another person at price $ 34.39 per share. | 13 Jan 2020 | 500 | 14,000 (0%) | 0% | 34.4 | 17,195 | Common Stock |
| Marianne De Backer | Director | Purchase of securities on an exchange or from another person at price $ 28.60 per share. | 13 Jan 2020 | 500 | 14,500 (0%) | 0% | 28.6 | 14,300 | Common Stock |
| Marianne De Backer | Director | Purchase of securities on an exchange or from another person at price $ 23.94 per share. | 13 Jan 2020 | 500 | 15,500 (0%) | 0% | 23.9 | 11,970 | Common Stock |
| Marianne De Backer | Director | Purchase of securities on an exchange or from another person at price $ 35.40 per share. | 13 Jan 2020 | 500 | 16,000 (0%) | 0% | 35.4 | 17,700 | Common Stock |
| Marianne De Backer | Director | Purchase of securities on an exchange or from another person at price $ 31.33 per share. | 13 Jan 2020 | 500 | 16,500 (0%) | 0% | 31.3 | 15,665 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 60.99 per share. | 06 Jan 2020 | 1,300 | 858,993 (0%) | 0% | 61.0 | 79,287 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 60.37 per share. | 06 Jan 2020 | 22,466 | 860,293 (0%) | 0% | 60.4 | 1,356,272 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 59.57 per share. | 06 Jan 2020 | 11,847 | 882,759 (0%) | 0% | 59.6 | 705,726 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 60.40 per share. | 06 Jan 2020 | 11,907 | 391,685 (0%) | 0% | 60.4 | 719,183 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 59.60 per share. | 06 Jan 2020 | 7,593 | 403,592 (0%) | 0% | 59.6 | 452,543 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 60.95 per share. | 06 Jan 2020 | 500 | 391,185 (0%) | 0% | 61.0 | 30,475 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 59.61 per share. | 06 Jan 2020 | 5,594 | 267,406 (0%) | 0% | 59.6 | 333,458 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 61.02 per share. | 06 Jan 2020 | 100 | 258,375 (0%) | 0% | 61.0 | 6,102 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 60.43 per share. | 06 Jan 2020 | 8,931 | 258,475 (0%) | 0% | 60.4 | 539,700 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 250,000 | 894,606 (0%) | 0% | 0 | Common Stock | |
| Douglas B. Given | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 8,000 | 180,925 (0%) | 0% | 0 | Common Stock | |
| Michael S. Perry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 8,000 | 44,000 (0%) | 0% | 0 | Common Stock | |
| Christopher Anzalone | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 900,000 | 2,705,237 (2%) | 0% | 0 | Common Stock | |
| Kenneth Myszkowski | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 85,000 | 411,185 (0%) | 0% | 0 | Common Stock | |
| Mauro Ferrari | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 7,500 | 14,400 (0%) | 0% | 0 | Common Stock | |
| William D. Waddill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 7,500 | 54,000 (0%) | 0% | 0 | Common Stock | |
| Patrick O'Brien | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 70,000 | 273,000 (0%) | 0% | 0 | Common Stock | |
| Marianne De Backer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2020 | 7,500 | 12,500 (0%) | 0% | 0 | Common Stock | |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 63.50 per share. | 24 Dec 2019 | 83,333 | 1,805,237 (1%) | 0% | 63.5 | 5,291,646 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 67.31 per share. | 12 Dec 2019 | 58,059 | 1,990,625 (1%) | 0% | 67.3 | 3,907,951 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 66.82 per share. | 12 Dec 2019 | 23,219 | 2,048,684 (2%) | 0% | 66.8 | 1,551,494 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 68.18 per share. | 12 Dec 2019 | 3,393 | 1,888,570 (1%) | 0% | 68.2 | 231,335 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 67.30 per share. | 12 Dec 2019 | 25,412 | 1,891,963 (1%) | 0% | 67.3 | 1,710,228 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 66.47 per share. | 12 Dec 2019 | 45,577 | 1,917,375 (1%) | 0% | 66.5 | 3,029,503 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 65.85 per share. | 12 Dec 2019 | 8,951 | 1,962,952 (1%) | 0% | 65.8 | 589,423 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 69.41 per share. | 12 Dec 2019 | 8,379 | 1,971,903 (1%) | 0% | 69.4 | 581,586 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 68.51 per share. | 12 Dec 2019 | 10,343 | 1,980,282 (1%) | 0% | 68.5 | 708,599 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 67.63 per share. | 02 Dec 2019 | 7,193 | 2,108,967 (2%) | 0% | 67.6 | 486,463 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 62.00 per share. | 02 Dec 2019 | 8,022 | 2,071,903 (2%) | 0% | 62 | 497,364 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.73 per share. | 02 Dec 2019 | 4,011 | 2,079,925 (2%) | 0% | 60.7 | 243,588 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 72.95 per share. | 02 Dec 2019 | 3,656 | 2,083,936 (2%) | 0% | 72.9 | 266,705 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 72.13 per share. | 02 Dec 2019 | 3,800 | 2,087,592 (2%) | 0% | 72.1 | 274,094 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 70.72 per share. | 02 Dec 2019 | 2,448 | 2,091,392 (2%) | 0% | 70.7 | 173,123 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 69.50 per share. | 02 Dec 2019 | 6,617 | 2,093,840 (2%) | 0% | 69.5 | 459,882 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 68.50 per share. | 02 Dec 2019 | 8,510 | 2,100,457 (2%) | 0% | 68.5 | 582,935 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 66.58 per share. | 02 Dec 2019 | 5,743 | 2,116,160 (2%) | 0% | 66.6 | 382,369 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2019 | 12,649 | 149,467 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 05 Nov 2019 | 12,649 | 326,185 (0%) | 0% | 5.2 | 65,648 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.75 per share. | 01 Nov 2019 | 37,884 | 351,420 (0%) | 0% | 7.8 | 293,601 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2019 | 37,884 | 162,116 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 41.21 per share. | 01 Nov 2019 | 16,620 | 313,536 (0%) | 0% | 41.2 | 684,910 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 40.56 per share. | 01 Nov 2019 | 21,264 | 330,156 (0%) | 0% | 40.6 | 862,468 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 31.83 per share. | 10 Oct 2019 | 56,325 | 2,121,903 (2%) | 0% | 31.8 | 1,792,825 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.20 per share. | 10 Oct 2019 | 56,325 | 2,178,228 (2%) | 0% | 5.2 | 292,890 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Oct 2019 | 56,325 | 945,543 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.25 per share. | 25 Sep 2019 | 20,000 | 2,121,903 (2%) | 0% | 28.3 | 565,000 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.04 per share. | 20 Sep 2019 | 12,673 | 2,141,903 (2%) | 0% | 29.0 | 368,024 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.00 per share. | 20 Sep 2019 | 53,972 | 2,154,576 (2%) | 0% | 28 | 1,511,216 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.10 per share. | 20 Sep 2019 | 66,645 | 2,208,548 (2%) | 0% | 5.1 | 339,890 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.04 per share. | 20 Sep 2019 | 41,755 | 2,141,903 (2%) | 0% | 29.0 | 1,212,565 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.10 per share. | 20 Sep 2019 | 41,755 | 2,183,658 (2%) | 0% | 5.1 | 212,951 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.10 per share. | 20 Sep 2019 | 4,250 | 2,146,153 (2%) | 0% | 5.1 | 21,675 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.00 per share. | 20 Sep 2019 | 4,250 | 2,141,903 (2%) | 0% | 29 | 123,250 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Sep 2019 | 66,645 | 1,001,868 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Sep 2019 | 41,755 | 1,068,513 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Sep 2019 | 4,250 | 1,110,268 | - | - | Stock Option (right to buy) | |
| Michael S. Perry | None | Sale of securities on an exchange or to another person at price $ 28.90 per share. | 09 Sep 2019 | 100,000 | 121,000 (0%) | 0% | 28.9 | 2,890,000 | Common Stock |
| Michael S. Perry | None | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 09 Sep 2019 | 85,000 | 36,000 (0%) | 0% | 30 | 2,550,000 | Common Stock |
| Mauro Ferrari | None | Sale of securities on an exchange or to another person at price $ 27.61 per share. | 26 Jun 2019 | 17,756 | 1,900 (0%) | 0% | 27.6 | 490,243 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 31 May 2019 | 20,000 | 313,536 (0%) | 0% | 5.2 | 103,800 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 May 2019 | 20,000 | 200,000 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 May 2019 | 15,000 | 220,000 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.60 per share. | 31 May 2019 | 15,000 | 293,536 (0%) | 0% | 4.6 | 69,000 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 24.88 per share. | 28 May 2019 | 30,000 | 203,000 (0%) | 0% | 24.9 | 746,400 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 May 2019 | 9,376 | 1,133,418 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 May 2019 | 40,072 | 1,142,794 | - | - | Stock Option (right to buy) | |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.62 per share. | 24 May 2019 | 9,376 | 2,141,903 (2%) | 0% | 2.6 | 24,565 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.01 per share. | 24 May 2019 | 40,072 | 2,132,527 (2%) | 0% | 2.0 | 80,545 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 22.00 per share. | 21 May 2019 | 27,071 | 278,536 (0%) | 0% | 22 | 595,562 | Common Stock |
| Christopher Anzalone | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 19.30 per share. | 03 Apr 2019 | 50,000 | 2,092,455 (2%) | 0% | 19.3 | 965,000 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.99 per share. | 01 Mar 2019 | 42,500 | 644,606 (0%) | 0% | 20.0 | 849,575 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.01 per share. | 01 Mar 2019 | 42,500 | 687,106 (0%) | 0% | 2.0 | 85,425 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2019 | 42,500 | 350,000 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Feb 2019 | 42,500 | 392,500 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.98 per share. | 25 Feb 2019 | 42,500 | 644,606 (0%) | 0% | 19.0 | 806,650 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.01 per share. | 25 Feb 2019 | 42,500 | 687,106 (0%) | 0% | 2.0 | 85,425 | Common Stock |
| Douglas B. Given | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2019 | 18,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Douglas B. Given | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2019 | 30,000 | 35,000 | - | - | Stock Option (right to buy) | |
| Douglas B. Given | None | Sale of securities on an exchange or to another person at price $ 19.25 per share. | 22 Feb 2019 | 65,000 | 175,130 (0%) | 0% | 19.3 | 1,251,250 | Common Stock |
| Douglas B. Given | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share. | 22 Feb 2019 | 7,000 | 240,130 (0%) | 0% | 4.8 | 33,250 | Common Stock |
| Douglas B. Given | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.62 per share. | 22 Feb 2019 | 10,000 | 233,130 (0%) | 0% | 2.6 | 26,200 | Common Stock |
| Douglas B. Given | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.19 per share. | 22 Feb 2019 | 18,000 | 223,130 (0%) | 0% | 2.2 | 39,420 | Common Stock |
| Douglas B. Given | None | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 22 Feb 2019 | 3,000 | 175,130 (0%) | 0% | 18.1 | 54,150 | Common Stock |
| Douglas B. Given | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 22 Feb 2019 | 30,000 | 205,130 (0%) | 0% | 5.2 | 155,700 | Common Stock |
| Douglas B. Given | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2019 | 7,000 | 0 | - | - | Stock Option (right to buy) | |
| Douglas B. Given | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2019 | 10,000 | 7,000 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 19 Feb 2019 | 8,000 | 305,607 (0%) | 0% | 18 | 144,000 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Feb 2019 | 8,000 | 235,000 | - | - | Stock Option (right to buy) | |
| Kenneth Myszkowski | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.20 per share. | 19 Feb 2019 | 8,000 | 313,607 (0%) | 0% | 5.2 | 41,600 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.01 per share. | 15 Feb 2019 | 42,500 | 687,106 (0%) | 0% | 2.0 | 85,425 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.67 per share. | 15 Feb 2019 | 26,250 | 644,606 (0%) | 0% | 17.7 | 463,838 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Feb 2019 | 42,500 | 435,000 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.98 per share. | 15 Feb 2019 | 42,500 | 644,606 (0%) | 0% | 18.0 | 764,150 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2019 | 42,500 | 477,500 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2019 | 11,667 | 520,000 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2019 | 11,667 | 531,667 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.06 per share. | 08 Feb 2019 | 42,500 | 670,856 (0%) | 0% | 17.1 | 725,050 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.01 per share. | 08 Feb 2019 | 42,500 | 713,356 (0%) | 0% | 2.0 | 85,425 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 16.48 per share. | 08 Feb 2019 | 57,000 | 670,856 (0%) | 0% | 16.5 | 939,360 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 15.66 per share. | 08 Feb 2019 | 97,167 | 727,856 (0%) | 0% | 15.7 | 1,521,635 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.62 per share. | 08 Feb 2019 | 11,667 | 825,023 (0%) | 0% | 2.6 | 30,568 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 15.34 per share. | 08 Feb 2019 | 46,167 | 813,356 (0%) | 0% | 15.3 | 708,202 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.62 per share. | 08 Feb 2019 | 11,667 | 859,523 (0%) | 0% | 2.6 | 30,568 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 14.48 per share. | 05 Feb 2019 | 22,500 | 847,856 (0%) | 0% | 14.5 | 325,800 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 13.85 per share. | 01 Feb 2019 | 28,500 | 870,356 (0%) | 0% | 13.9 | 394,725 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 13.15 per share. | 22 Jan 2019 | 17,500 | 898,856 (0%) | 0% | 13.2 | 230,125 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 13.59 per share. | 22 Jan 2019 | 152,000 | 916,356 (0%) | 0% | 13.6 | 2,065,680 | Common Stock |
| Douglas B. Given | None | Sale of securities on an exchange or to another person at price $ 13.58 per share. | 22 Jan 2019 | 3,000 | 178,130 (0%) | 0% | 13.6 | 40,740 | Common Stock |
| Patrick O'Brien | General Counsel | Sale of securities on an exchange or to another person at price $ 14.43 per share. | 18 Jan 2019 | 72,000 | 233,000 (0%) | 0% | 14.4 | 1,038,960 | Common Stock |
| Kenneth Myszkowski | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 14.55 per share. | 17 Jan 2019 | 81,875 | 305,607 (0%) | 0% | 14.5 | 1,191,281 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.62 per share. | 14 Jan 2019 | 11,666 | 1,110,022 (1%) | 0% | 2.6 | 30,565 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 14.40 per share. | 14 Jan 2019 | 42,666 | 1,068,356 (1%) | 0% | 14.4 | 614,390 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.20 per share. | 14 Jan 2019 | 1,000 | 1,111,022 (1%) | 0% | 6.2 | 6,200 | Common Stock |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jan 2019 | 1,000 | 543,334 | - | - | Stock Option (right to buy) | |
| Bruce D. Given | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jan 2019 | 11,666 | 544,334 | - | - | Stock Option (right to buy) | |
| Zhen Li | Snr. VP, Chem and Non-Clin Dev | Sale of securities on an exchange or to another person at price $ 14.34 per share. | 14 Jan 2019 | 40,500 | 201,700 (0%) | 0% | 14.3 | 580,770 | Common Stock |
| William D. Waddill | None | Sale of securities on an exchange or to another person at price $ 14.77 per share. | 11 Jan 2019 | 8,500 | 46,500 (0%) | 0% | 14.8 | 125,545 | Common Stock |
| Mauro Ferrari | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2019 | 3,429 | 19,656 (0%) | 0% | 0 | Common Stock | |
| Bruce D. Given | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2019 | 210,000 | 1,118,356 (1%) | 0% | 0 | Common Stock | |
| Bruce D. Given | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 11.98 per share. | 01 Jan 2019 | 20,000 | 1,098,356 (1%) | 0% | 12.0 | 239,600 | Common Stock |